Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord.

@article{Wilcock2007MitoticSO,
  title={Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord.},
  author={Arwen C. Wilcock and Jason R. Swedlow and Kate G Storey},
  journal={Development},
  year={2007},
  volume={134 10},
  pages={1943-54}
}
Despite great insight into the molecular mechanisms that specify neuronal cell type in the spinal cord, cell behaviour underlying neuron production in this tissue is largely unknown. In other neuroepithelia, divisions with a perpendicular cleavage plane at the apical surface generate symmetrical cell fates, whereas a parallel cleavage plane generates asymmetric daughters, a neuron and a progenitor in a stem cell mode, and has been linked to the acquisition of neuron-generating ability. Using a… CONTINUE READING
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