Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

  title={Mitotic regulation of the human anaphase-promoting complex by phosphorylation.},
  author={Claudine Kraft and Franz Herzog and Christian Gieffers and Karl Mechtler and Anja Hagting and Jonathon Pines and J. G. Peters},
  journal={The EMBO journal},
  volume={22 24},
The anaphase-promoting complex (APC) or cyclosome is a ubiquitin ligase that initiates anaphase and mitotic exit. APC activation is thought to depend on APC phosphorylation and Cdc20 binding. We have identified 43 phospho-sites on APC of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7. In vitro, at least 15 of the mitotic phospho-sites can be generated by cyclin-dependent… CONTINUE READING
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Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

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