Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2.

@article{Jesch2001MitoticPO,
  title={Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2.},
  author={Stephen A. Jesch and Timothy S. Lewis and Natalie G Ahn and Adam D. Linstedt},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 6},
  pages={
          1811-7
        }
}
The role of the mitogen-activated protein kinase kinase (MKK)/extracellular-activated protein kinase (ERK) pathway in mitotic Golgi disassembly is controversial, in part because Golgi-localized targets have not been identified. We observed that Golgi reassembly stacking protein 55 (GRASP55) was phosphorylated in mitotic cells and extracts, generating a mitosis-specific phospho-epitope recognized by the MPM2 mAb. This phosphorylation was prevented by mutation of ERK consensus sites in GRASP55… CONTINUE READING