Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability

@article{Kharat2016MitoticPO,
  title={Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability},
  author={Sagar Kharat and Vivek Tripathi and Arun Prasath Damodaran and Raina Priyadarshini and Somnath Chandra and Shweta Tikoo and Ramadass Nandhakumar and Vivek Srivastava and S. Mohana Priya and Mansoor Hussain and Sarabpreet Kaur and Jordan B. Fishman and Susanta Sengupta},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={1025-1038}
}
Mutations in Bloom helicase (BLM) lead to Bloom Syndrome (BS). BS is characterized by multiple clinical manifestations including predisposition to a wide spectrum of cancers. Studies have revealed the mechanism of BLM recruitment after stalled replication and its role during the repair of DNA damage. We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2… CONTINUE READING

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