Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

Abstract

Mitotic spindle formation and chromosome segregation depend critically on kinetochore-microtubule (KT-MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C. elegans, was recently shown to regulate KT localization of dynein, but depletion phenotypes revealed striking differences, suggesting evolutionarily diverse roles of mitotic… (More)
DOI: 10.1083/jcb.200812167

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