Mitotic chromosomal instability and cancer: mouse modelling of the human disease

Abstract

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy is associated with increases in genomic instability. Mitotic chromosomal instability — the inability to faithfully segregate equal chromosome complements to two daughter cells during mitosis — is a widespread phenomenon in solid tumours that is thought to serve as… (More)
DOI: 10.1038/nrc2781

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@article{Schvartzman2010MitoticCI, title={Mitotic chromosomal instability and cancer: mouse modelling of the human disease}, author={Juan-Manuel Schvartzman and Rocio Sotillo and Robert Benezra}, journal={Nature Reviews Cancer}, year={2010}, volume={10}, pages={102-115} }