Mitotic checkpoint genes, hsMAD2 and BubR1, in oesophageal squamous cancer cells and their association with 5-fluorouracil and cisplatin-based radiochemotherapy.

@article{Tanaka2008MitoticCG,
  title={Mitotic checkpoint genes, hsMAD2 and BubR1, in oesophageal squamous cancer cells and their association with 5-fluorouracil and cisplatin-based radiochemotherapy.},
  author={Koji Tanaka and Yasuhiko Mohri and Michi Ohi and Tuyoshi Yokoe and Yuhki Koike and Yuhki Morimoto and Chikao Miki and Hitoshi Tonouchi and Masato Kusunoki},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={2008},
  volume={20 8},
  pages={639-46}
}
AIMS HsMAD2 and BubR1 are crucial components of a functional mitotic checkpoint. Recently, impaired mitotic checkpoints or decreased expression of mitotic checkpoint genes have been associated with sensitivity to certain anticancer drugs. The current study aimed to evaluate the association of hsMAD2 and BubR1 with sensitivity to various anticancer drugs in oesophageal squamous cell carcinoma (ESCC) cell lines. We also investigated responses to 5-fluorouracil and cisplatin-based… CONTINUE READING

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Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2005

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