Mitotic catastrophe as a consequence of chemotherapy.

  title={Mitotic catastrophe as a consequence of chemotherapy.},
  author={Sylvia Mansilla and M. Bataller and J. Portugal},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={6 6},
According to a widespread model, anti-cancer chemotherapy involves the triggering of tumor cells to undergo apoptosis, so apoptosis-resistant cells would be recalcitrant to such therapy. However, in addition to apoptosis, which is mainly dependent on the activity of the tumor suppressor protein p53, cells can be eliminated following DNA damage by other mechanisms. Mitotic catastrophe, a form of cell death that results from abnormal mitosis, is one such mechanism. While the term mitotic… Expand
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