Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.

@article{Nakano2012MitoticAD,
  title={Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.},
  author={Yusuke Nakano and Toshiyuki Sumi and Masanari Morishita and Takeshi Fukuda and Hiroyuki Nobeyama and Hiroyuki Yoshida and Yoshinari Matsumoto and Tomoyo Yasui and Osamu Ishiko},
  journal={Oncology letters},
  year={2012},
  volume={3 2},
  pages={281-286}
}
Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. A compromised mitotic spindle checkpoint results in an abnormal number of chromosomes. This is referred to as chromosomal instability, and has been reported in most types of human cancer. The aim of this study was to examine the expression of MAD2 in mucinous ovarian tumors exhibiting varying degrees of malignancy. We reviewed 128 cases of mucinous ovarian tumors initially treated at Osaka City… CONTINUE READING