Mitotic aneuploidy as a possible mechanism for tumour promoting activity in bile acids.

@article{Ferguson1984MitoticAA,
  title={Mitotic aneuploidy as a possible mechanism for tumour promoting activity in bile acids.},
  author={Lynnette Robin Ferguson and James M. Parry},
  journal={Carcinogenesis},
  year={1984},
  volume={5 4},
  pages={447-51}
}
A range of conjugated and free bile acids were assayed for their ability to induce a variety of genetic endpoints in growing cells of yeast. None of the bile acids showed any activity in assays for the induction of mitotic crossing-over and mutation whereas the free bile acids lithocholic, chenodeoxycholic, deoxycholic and cholic acid were potent inducers of mitotic chromosome aneuploidy. In contrast, both conjugated bile acids, taurodeoxycholic and glycodeoxycholic lacked the ability to induce… CONTINUE READING

Similar Papers

Loading similar papers…