Mitotic Transcription Repression in Vivo in the Absence of Nucleosomal Chromatin Condensation

@article{Spencer2000MitoticTR,
  title={Mitotic Transcription Repression in Vivo in the Absence of Nucleosomal Chromatin Condensation},
  author={Charlotte A. Spencer and Michael J. Kruhlak and Heather L. Jenkins and Xuejun Sun and D. P. Bazett-Jones},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={13 - 26}
}
All nuclear RNA synthesis is repressed during the mitotic phase of the cell cycle. In addition, RNA polymerase II (RNAP II), nascent RNA and many transcription factors disengage from DNA during mitosis. It has been proposed that mitotic transcription repression and disengagement of factors are due to either mitotic chromatin condensation or biochemical modifications to the transcription machinery. In this study, we investigate the requirement for chromatin condensation in establishing mitotic… CONTINUE READING
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