Mitotic Kinases and p53 Signaling

@inproceedings{Ha2012MitoticKA,
  title={Mitotic Kinases and p53 Signaling},
  author={Geun-Hyoung Ha and Eun-Kyoung Breuer},
  booktitle={Biochemistry research international},
  year={2012}
}
Mitosis is tightly regulated and any errors in this process often lead to aneuploidy, genomic instability, and tumorigenesis. Deregulation of mitotic kinases is significantly associated with improper cell division and aneuploidy. Because of their importance during mitosis and the relevance to cancer, mitotic kinase signaling has been extensively studied over the past few decades and, as a result, several mitotic kinase inhibitors have been developed. Despite promising preclinical results… CONTINUE READING

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