Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

@inproceedings{Bopp2013MitoticEO,
  title={Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families},
  author={Selina E. R. Bopp and Micah J. Manary and Andrew Bright and Geoffrey L. Johnston and Neekesh V. Dharia and Fabio L. Luna and Susan McCormack and David M. Plouffe and Case W. McNamara and John R. Walker and David A. Fidock and Eros Lazzerini Denchi and Elizabeth A. Winzeler},
  booktitle={PLoS genetics},
  year={2013}
}
Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses through antigenic variation. At the global level, parasites escape drug pressure through single nucleotide variants and gene copy amplification events conferring drug resistance. Despite their importance to global health, the rates at which these genomic alterations emerge have not been determined. We studied the complete genomes of… CONTINUE READING
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