Mitotic Activity in the Primate Subependymal Layer and the Genesis of Gliomas

@article{Lewis1968MitoticAI,
  title={Mitotic Activity in the Primate Subependymal Layer and the Genesis of Gliomas},
  author={P. D. Lewis},
  journal={Nature},
  year={1968},
  volume={217},
  pages={974-975}
}
Globus and Kuhlenbeck1,2 drew attention to the presence beneath the lining of the cerebral ventricles of a distinct cell layer, which they named the subependymal cell plate. They demonstrated it in the brain of human infants, showed it to contain primitive cells and stressed its possible role in the development of certain paraventricular neoplasms. Various workers3–5 have shown the persistence of a subependymal layer in man from foetal to adult life, but except for explaining the origin of… Expand
The role of the subependymal plate in glial tumorigenesis
TLDR
These studies support the hypothesis of Globus and Kuhlenbeck, which implicates the cells of the subependymal plate in glial tumorigenesis in neonatal dogs. Expand
The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain
The fine structure of early cell proliferations induced transplacentally by ethylnitrosourea in the rat brain reveals that the cells show features of the undifferentiated cells of the subependymalExpand
Ependymal and subependymal cells of the caudato-pallial junction in the lateral ventricle of the neonatal rabbit
TLDR
The ultrastructural characteristics of a concentration of mitotically active cells near the lateral margin of the lateral ventricle was studied in the neonatal rabbit brain and the presence of intermediate forms with transitional cytologic features indicates simple and complex cells may represent different stages in the mitotic cycle of a single cell type. Expand
Cell proliferation in the subependymal layer of the postnatal marmoset, Callithrix jacchus.
Cells of the subependymal layer (SEL) have been shown to be capable of continued postnatal cell division throughout life in rodents. To determine if the primate brain behaves similarly, proliferativeExpand
The subependymal plate and associated ependyma in the dog. An ultrastructural study
TLDR
The fate of subependymal cells is discussed and it is concluded that a certain percentage diein situ while others may migrate either into the distant neuropil or form nests in the adjacent Neuropil. Expand
The subependyma of the primate, slow loris (Nycticebus coucang coucang).
  • E. Ling
  • Biology, Medicine
  • Tissue & cell
  • 1974
TLDR
The morphological evidence suggests that in parallel with the macroglia the microglia could be derived by stepwise transformation of the subependymal cells. Expand
The subependymal layer and neighboring region in the brain of the young rat
The subependymal layer found below the ependyma of the lateral ventricle, as well as the border area separating the layer from corpus callosum and caudate nucleus, were investigated in the brain ofExpand
A QUANTITATIVE STUDY OF THE MITOTIC ACTIVITY IN THE SUBEPENDYMAL PLATE OF ADULT RATS
  • J. Hopewell
  • Biology, Medicine
  • Cell and tissue kinetics
  • 1971
TLDR
It is shown that mitotic activity decreases with the increase in age of the animals, and in the case of animals of two strains of rats, of this age, the mitotic count is significantly higher in males than in females. Expand
Neurogenesis and gliogenesis in the human brain.
  • M. Berry
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986
TLDR
The primary germinal neural epithelium lines the ventricular system of the brain and shows intense mitotic activity, and has long been considered the site of original of periventricular gliomas. Expand
The subependymal layer in rodents: a site of structural plasticity and cell migration in the adult mammalian brain
TLDR
The subependymal layer is an area of the adult mammalian brain endowed with a cohort of phenomena proper of neural development, persisting into (and adapted to) the fully mature nervous tissue, an optimal model to unravel mechanisms permitting highly dynamic structural plasticity during adulthood. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
THE NORMAL HISTOLOGY OF INFANTS' BRAINS: WITH PARTICULAR REFERENCE TO ANATOMIC CHANGES IN THE BRAIN IN INTESTINAL INTOXICATION OF INFANTS
TLDR
An attempt was made by Goldzieher 1 to trace the extreme dehydration that characterizes this disease to pathologic alterations in the brain, particularly in parts of the diencephalon adjacent to the floor and walls of the third ventricle. Expand
THE MEDULLOBLAST AND THE MEDULLOBLASTOMA: A STUDY OF HUMAN EMBRYOS
The interest of neuropathologists in the cytogenesis of the nervous system became enhanced by the realization that gliomas contain cells resembling those seen in the brain during normal embryonicExpand
Subependymoma: A Newly Recognized Tumor of Subependymal Derivation
TLDR
The purpose is to describe the charac te r i s t ic histologic features of the t u m o r and to discuss its origin and its d i f ferent ia t ion f rom o the r types of gliomas. Expand
The post-mortem origin and mechanism of neuronal hyperchromatosis and nuclear pyknosis.
TLDR
The aim of fixation is to affix cellular membranes in such a manner that neurons are no longer vulnerable to traumatization incurred during autopsy and removal of the organ. Expand
Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions
TLDR
It was established that cells multiplying in the ependymal and subependymal walls of the Olfactory ventricle migrate outward into the olfactory bulb, where they become differentiated into granule cells, and, to a lesser extent, other types of nerve cells of the cerebellar cortex. Expand
Autoradiographic investigation of cell proliferation in the brains of rats and cats
  • J. Altman
  • Biology, Medicine
  • The Anatomical record
  • 1963
TLDR
The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores. Expand
THE RELATIONSHIP OF THE CELL CYCLE TO TUMOR GROWTH AND CONTROL OF CELL DIVISION: A REVIEW.
TLDR
Although the length of the cell cycle varies in different kinds of cells, it is shorter in certain cells of the adult animal than in some of the fastest growing tumors, so tumor growth must involve other kinetic parameters besides speed of cell proliferation. Expand
[AUTORADIOGRAPHIC STUDIES ON CELL DIVISION AND CELL DEVELOPMENT IN THE BRAIN OF ADULT MICE AND ADULT RHESUS APES AFTER INJECTION OF RADIOACTIVE THYMIDINE].
Bei erwachsenen Mausen und Rhesus-Affen werden Zellteilung und Zellentwicklung im Gehirn nach Injektion von H3-Thymidin mit der autoradiographischen Methode untersucht. Dabei kommen wir zu folgendenExpand
...
1
2
...