Mitotane effects in a H295R xenograft model of adjuvant treatment of adrenocortical cancer.

@article{Lindhe2010MitotaneEI,
  title={Mitotane effects in a H295R xenograft model of adjuvant treatment of adrenocortical cancer.},
  author={Orjan Lindhe and Britt M Skogseid},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2010},
  volume={42 10},
  pages={725-30}
}
Adrenocortical cancer is one of the most aggressive endocrine malignancies. Growth through the capsule or accidental release of cancer cells during surgery frequently results in metastatic disease. We investigated the antitumoral effect of 2 adrenocorticolytic compounds, O, P'-DDD and MeSO2-DDE, in the adrenocortical cell line H295R both in vitro and as a xenograft model in vivo. H295R cells were injected s. c. in nude mice. O, P'-DDD, MeSO2-DDE, or oil (control) was administered i. p., either… CONTINUE READING
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