Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.

@article{Sbiera2015MitotaneIS,
  title={Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.},
  author={Silviu Sbiera and Ellen Leich and Gerhard Liebisch and Iuliu Sbiera and Andreas Schirbel and Laura Wiemer and Silke Matysik and Carolin Eckhardt and Felix Gardill and Annemarie Gehl and Sabine Kendl and Isabel Weigand and Margarita Bala and Cristina L Ronchi and Timo Deutschbein and Gerd Schmitz and Andreas Rosenwald and Wim Van Biesen and Martin Fassnacht and Matthias Kroiss},
  journal={Endocrinology},
  year={2015},
  volume={156 11},
  pages={
          3895-908
        }
}
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and counteracts tumor growth and steroid hormone production. Despite serious adverse effects, mitotane has been clinically used for decades. Elucidation of its unknown molecular mechanism of action seems essential to develop better ACC therapies. Here, we set out to identify the molecular target of mitotane and altered downstream… CONTINUE READING
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Mitotane Revisited: A New Target for an Old Drug.

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