Mitosis is not a key target of microtubule agents in patient tumors

@article{KomldiPsztor2011MitosisIN,
  title={Mitosis is not a key target of microtubule agents in patient tumors},
  author={Edina Koml{\'o}di-P{\'a}sztor and Dan L. Sackett and Julia Wilkerson and Tito Fojo},
  journal={Nature Reviews Clinical Oncology},
  year={2011},
  volume={8},
  pages={244-250}
}
Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-targeting agents (MTAs) have a long record of success, usually attributed to the induction of mitotic arrest. Indeed, it was this success that led to the search for mitosis-specific inhibitors. We believe the clinical disappointment of mitosis-specific inhibitors stands as evidence that MTAs have been successful not only by interfering with mitosis but, more importantly, by disrupting essential… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

The proliferation rate paradox in antimitotic chemotherapy

Molecular biology of the cell • 2012
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 78 references

A phase I study of XL228, a multitargeted protein kinase inhibitor, in patients (pts) with solid tumors or multiple myeloma [abstract

Smith, C D.
J. Clin. Oncol • 2010

the key players

Etienne-Manneville, S. From signaling pathways to microtubule dynamics
Curr. Opin. Cell Biol. 22, 104–111 • 2010

Similar Papers

Loading similar papers…