Mitosis is not a key target of microtubule agents in patient tumors

  title={Mitosis is not a key target of microtubule agents in patient tumors},
  author={Edina Koml{\'o}di-P{\'a}sztor and Dan L. Sackett and Julia Wilkerson and Tito Fojo},
  journal={Nature Reviews Clinical Oncology},
Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-targeting agents (MTAs) have a long record of success, usually attributed to the induction of mitotic arrest. Indeed, it was this success that led to the search for mitosis-specific inhibitors. We believe the clinical disappointment of mitosis-specific inhibitors stands as evidence that MTAs have been successful not only by interfering with mitosis but, more importantly, by disrupting essential… CONTINUE READING

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