Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

@inproceedings{Ashrafi2014MitophagyOD,
  title={Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin},
  author={Ghazaleh Ashrafi and Julia S. Schlehe and Matthew J Lavoie and Thomas L Schwarz},
  booktitle={The Journal of cell biology},
  year={2014}
}
To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from the soma where most lysosomal degradation is thought to occur. In this paper, we report that PINK1 and Parkin, two Parkinson's disease-associated proteins, mediate local mitophagy of dysfunctional mitochondria in neuronal axons. To reduce cytotoxicity and mimic physiological levels of mitochondrial damage, we… CONTINUE READING