Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.

@article{Mendl2011MitophagyIY,
  title={Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.},
  author={Nadine Mendl and Angelo Occhipinti and Matthias Mueller and Philipp S Wild and Ivan Dikic and Andreas S. Reichert},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 8},
  pages={
          1339-50
        }
}
Dysfunctional mitochondria show a reduced capacity for fusion and, as mitochondrial fission is maintained, become spatially separated from the intact network. By that mechanism, dysfunctional mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy of… CONTINUE READING

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