Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.

  title={Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.},
  author={Sarah Pickles and Pierre Vigi{\'e} and Richard J Youle},
  journal={Current biology : CB},
  volume={28 4},
The maintenance of a healthy and functional mitochondrial network is critical during development as well as throughout life in the response to physiological adaptations and stress conditions. Owing to their role in energy production, mitochondria are exposed to high levels of reactive oxygen species, making them particularly vulnerable to mitochondrial DNA mutations and protein misfolding. Given that mitochondria are formed from proteins encoded by both nuclear and mitochondrial genomes, an… CONTINUE READING
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