Mitophagy and Parkinson's disease: The PINK1–parkin link☆

  title={Mitophagy and Parkinson's disease: The PINK1–parkin link☆},
  author={Emma Deas and Nicholas Wood and Helene Plun-Favreau},
  booktitle={Biochimica et biophysica acta},
The study of rare, inherited mutations underlying familial forms of Parkinson's disease has provided insight into the molecular mechanisms of disease pathogenesis. Mutations in these genes have been functionally linked to several key molecular pathways implicated in other neurodegenerative disorders, including mitochondrial dysfunction, protein accumulation and the autophagic-lysosomal pathway. In particular, the mitochondrial kinase PINK1 and the cytosolic E3 ubiquitin ligase parkin act in a… CONTINUE READING