Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

  title={Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.},
  author={Jesse S. Kerr and Bryan A Adriaanse and Nigel H. Greig and Mark P. Mattson and Muhammed Z Cader and Vilhelm A. Bohr and Evandro Fei Fang},
  journal={Trends in neurosciences},
  volume={40 3},
Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (Aβ) and Tau pathologies. Emerging findings suggest that the autophagy/lysosome pathway that removes damaged mitochondria (mitophagy) is also compromised in AD, resulting in the accumulation of dysfunctional mitochondria. Results in animal and cellular models of AD and in patients with sporadic late-onset AD suggest… CONTINUE READING
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