Mitomycin and Amniotic Membrane: A New Method of Reducing Adhesions and Fibrosis in Strabismus Surgery

  title={Mitomycin and Amniotic Membrane: A New Method of Reducing Adhesions and Fibrosis in Strabismus Surgery},
  author={James P Kersey and Anthony J. Vivian},
  pages={116 - 118}
The effectiveness of complex strabismus surgery is often limited by the development of fibrosis postoperatively. The use of mitomycin C to reduce fibrosis in strabismus surgery has been reported, but the use of amniotic membrane has not. We describe a technique which uses both mitomycin C and amniotic membrane patches to reduce fibrosis. We describe this technique for two patients with complex strabismus who were treated with this technique. 

The Use of Amniotic Membrane in the Management of Strabismus Reoperation Cases

It is believed that amniotic membrane placement between the extra ocular muscle, sclera and tenon tissue improves the ductions by inhibiting post-operative scar formation.

Amniotic membrane implantation to reduce extraocular muscle adhesions to a titanium implant.

  • Reshma A. MehendaleL. Dagi
  • Medicine
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • 2011

The Use of Amniotic Membrane for the Management of Fibrosis in Complex Strabismus Surgery

Surgical management with amniotic membrane transplant in 8 strabismus cases between 2007 and 2010 indicates that AMT is beneficial, but it is suggested it be used in the early stages of the surgical management of these cases.

Amniotic membrane for reducing the formation of adhesions in strabismus surgery: experimental study in rabbits.

Human amniotic membrane in rabbits led to an increase in the inflammatory process and a decrease in fibrosis formation following strabismus surgery.

Amniotic Membrane Transplantation in Strabismus Surgery

Cryopreserved AM transplantation was safe and histopathologically effective in preventing adhesions, and its use during strabismus reoperations is merited if previous recommendations and precautions are considered.

Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery

The use of dried human AM was not effective in controlling the postoperative inflammation and scarring in rabbit eyes after extraocular muscle surgery, however, this may be due to the devitalized dry preparation of human AM (Ambiodry2), which may have lost the expected anti-inflammatory and anti-scarring properties.

Effect of cryopreserved amniotic membrane on the development of adhesions and fibrosis after extraocular muscle surgery in rabbits

Purpose:  To histopathologically evaluate the effect of cryopreserved human amniotic membrane (AM) transplant on preventing the development of postoperative adhesions after extraocular muscle surgery.

Amniotic membrane in the management of strabismus reoperations

Amniotic membrane placement around the extraocular muscle improves the duction and decreases the residual angle of deviations by inhibiting postoperative scar formation.

Treatment and prevention of ocular motility restrictions with amniotic membrane transplantation

Significant improvement was reported in most patients after the use of amniotic membrane transplantation to treat or prevent ocular motility limitations, and the cryopreservation method was more widely used, presenting a good safety profile with few adverse effects in the short and medium term.



Effectiveness of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.

Intraoperative application of mitomycin C (0.2 mg/mL for 5 minutes) is a safe and effective adjunct to surgery in the treatment of restrictive strabismus and had better range of passive ductions than controls.

Trabeculectomy with the use of amniotic membrane for uncontrollable glaucoma.

A new surgical technique for uncontrollable glaucoma that uses amniotic membrane to prevent postoperative adhesion of conjunctiva and sclera is developed and it is suggested that this technique is efficacious for the reduction of intraocular pressure in high-risk glAUcoma patients.

Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery.

Amniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment

It was showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pteryGium.

Delayed corneal epitheliopathy after antimetabolite-augmented trabeculectomy.

The first case of delayed antimetabolite-related corneal epithelial toxicity after trabeculectomy and its successful treatment with limbal stem cell transplantation is described.

Mitomycin: clinical applications in ophthalmic practice.

Mitomycin (mitomycin C; MMC) is an antibiotic isolated from Streptomyces caespitosus that undergoes metabolic reductive activation, and has various oxygen tension-dependent cytotoxic effects on cells, including the cross-linking of DNA.