[Mitomycin C induced structural changes in heterochromatic regions of human chromosomes 1, 9, 16 and Y].

Abstract

Aberrations and variations in the heterochromatic blocks of chromosomes 1, 9, 16 and Y were found under the influence of mitomycin C in cultured lymphocytes of peripheral human blood. Lymphocytes were cultured during 96 hours, mitomycin C in final concentration of 0.3 mkg/ml was present in the culture during the latest 24 hours of culturing. Different changes in the heterochromatic regions of chromosomes were found in approximately 30% of cells: in 6.3% of cells mitotic chiasmata were indicated. In 9.5% of cells isolocus breaks were observed in heterochromatic region of chromosome 1 in segment 1q11. In the latter case this may be a fragile site detected under the influence of mitomycin C on the lymphocytes.

Cite this paper

@article{Malygina1988MitomycinCI, title={[Mitomycin C induced structural changes in heterochromatic regions of human chromosomes 1, 9, 16 and Y].}, author={N. A. Malygina and O G Remizova and A P Akuf'ev}, journal={Tsitologiia}, year={1988}, volume={30 11}, pages={1350-4} }