Mitomycin-C-induced sister-chromatid exchanges and cell-cycle kinetics in lymphocytes from patients with Klinefelter syndrome.

@article{Yamagata1989MitomycinCinducedSE,
  title={Mitomycin-C-induced sister-chromatid exchanges and cell-cycle kinetics in lymphocytes from patients with Klinefelter syndrome.},
  author={Zentaro Yamagata and Sumio Iijima and Tatsuya Takeshita and C Ariizumi and Makoto Higurashi},
  journal={Mutation research},
  year={1989},
  volume={212 2},
  pages={263-8}
}
The chromosomal sensitivity to mitomycin-C (MMC) and cell-cycle kinetics in cells from patients with Klinefelter syndrome, a sex chromosomal disorder giving a high risk of malignant tumor, were studied by techniques of sister-chromatid exchanges (SCEs). The frequencies of MMC-induced SCEs increased in proportion to the increase in MMC concentration in both patient and normal control cells. At low levels of MMC there were no significant differences in SCE frequencies between the patient and… CONTINUE READING

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