Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.

Abstract

Mitomycin C (MMC) has been evaluated in combination with several antitumor agents. Full dose response curves were established for all drugs and drug combinations. Synergy was shown with MMC plus either cyclophosphamide (CYC) or methotrexate (MTX). In testing MMC and CYC against P388 leukemia, the combined treatment yielded a 75% rate of long-term survivors… (More)

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@article{Mabel1983MitomycinCC, title={Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.}, author={J A Mabel and Isidore Wodinsky}, journal={Cancer}, year={1983}, volume={51 4}, pages={600-5} }