Mitomycin C and menadione for the treatment of lung cancer: a phase II trial

  title={Mitomycin C and menadione for the treatment of lung cancer: a phase II trial},
  author={Merry L. Tetef and Kim A Margolin and Chul Ahn and Steven A. Akman and Warren A. Chow and Lucille A. Leong and Robert J. Jr. Morgan and James W. Raschko and George Somlo and James H. Doroshow},
  journal={Investigational New Drugs},
SummaryA phase II trial of menadione [2.5 gm/m2 as a continuous intravenous (iv) infusion over 48 hours] followed by mitomycin C (10–20 mg/m2 iv bolus) administered every 4 to 6 weeks was performed in 23 patients with advanced lung cancer. Menadione, a vitamin K analog which lowers intracellular pools of reduced glutathione (GSH), was combined with mitomycin C in an attempt to overcome thiol-mediated resistance to alkylating agent chemotherapy. The median age of patients entered on this trial… 

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A phase I trial of M in patients with advanced cancer with median patient age, Karnofsky performance status, and number of prior chemotherapy regimens, finding no objective partial or complete responses was observed.

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