• DOI:10.1038/ncb1491
Corpus ID: 8686894

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

@article{Takahashi2006MitogenicSA,
  title={Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence},
  author={A. Takahashi and N. Ohtani and Kimi Yamakoshi and S. Iida and H. Tahara and K. Nakayama and T. Ide and H. Saya and E. Hara},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={1291-1297}
}

A. Takahashi, N. Ohtani, +7 authors E. Hara

Published 2006

Medicine, Biology

Nature Cell Biology

The p16INK4a cyclin-dependent kinase inhibitor has a key role in establishing stable G1 cell-cycle arrest through activating the retinoblastoma (Rb) tumour suppressor protein pRb in cellular senescence. Here, we show that the p16INK4a /Rb-pathway also cooperates with mitogenic signals to induce elevated intracellular levels of reactive oxygen species (ROS), thereby activating protein kinase Cδ (PKCδ) in human senescent cells. Importantly, once activated by ROS, PKCδ promotes further generation… CONTINUE READING

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