Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

  title={Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor},
  author={Dr. Maya Ish-Shalom and Claus T Christoffersen and Peter Vorwerk and Nina Sacerdoti-Sierra and Ronald M. Shymko and David Naor and Professor P. De Meyts},
Insulin has traditionally been considered as a hormone essential for metabolic regulation, while the insulin-like growth factors (IGF-I and IGF-II) are postulated to be more specifically involved in growth regulation. The conventional wisdom is that they share each other's effects only at high concentrations, due to their weak affinity for the heterologous receptor. We discuss here the evidence that in the proper cellular context, insulin can be mitogenic at physiologic concentrations through… CONTINUE READING


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Role of the time factor in signalling specificity. Application to mitogenic and metabolic signalling by the insulin and insulinlike growth factor-I receptor tyrosine kinases

  • P De Meyts, CT Christoffersen, B Ursø
  • Metabolism
  • 1995
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