Mitogenic growth factors in breast fluid obtained from healthy women: evaluation of biological and extraneous sources of variability.

@article{Gann1997MitogenicGF,
  title={Mitogenic growth factors in breast fluid obtained from healthy women: evaluation of biological and extraneous sources of variability.},
  author={Peter H. Gann and Robert Chatterton and Kirsten M Vogelsong and Jehan Dupuis and A B Ellman},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1997},
  volume={6 6},
  pages={421-8}
}
Peptide growth factors (GFs), including epidermal GF (EGF) and transforming GF-alpha (TGF-alpha), are presumed to play an important role in the local regulation of breast cell proliferation. Breast fluid collected by nipple aspiration provides a potential means to assess the concentration of these factors in contact with the ductal epithelium. Although identification of immunoreactive EGF-like GFs in breast fluid has been reported previously, we performed this study to evaluate the sensitivity… CONTINUE READING

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