Mitogenic function of human procathepsin D: the role of the propeptide.

  title={Mitogenic function of human procathepsin D: the role of the propeptide.},
  author={Martin Fusek and V{\'a}clav Větvi{\vc}ka},
  journal={The Biochemical journal},
  volume={303 ( Pt 3)},
The proform of cathepsin D is secreted by some human breast-cancer cell lines upon stimulation with oestrogen. In these cell lines, procathepsin D was described to act as an autocrine mitogen, and a correlation between the cathepsin D concentration in tumour tissues and poor prognosis for the patient was demonstrated in several independent investigations. In the present study, we focused on the mechanism of procathepsin D mitogenic activity. Procathepsin D isolated from secretions of ZR-75-1… CONTINUE READING

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