Mitogenic factors promoting intestinal smooth muscle cell proliferation.

  title={Mitogenic factors promoting intestinal smooth muscle cell proliferation.},
  author={Roger D P Stanzel and Sandra R Lourenssen and Dileep G Nair and M G Blennerhassett},
  journal={American journal of physiology. Cell physiology},
  volume={299 4},
Intestinal smooth muscle cells are normally quiescent, but in the widely studied model of trinitrobenzene sulfonic acid (TNBS)-induced colitis in the rat, the onset of inflammation causes proliferation that leads to increased cell number and an altered phenotype. The factors that drive this are unclear and were studied in primary cultures of circular smooth muscle cells (CSMC) from the rat colon. While platelet-derived growth factor (PDGF)-AA, fibroblast growth factor (FGF), and epidermal… CONTINUE READING