Mitogenic activity of (-)epigallocatechin gallate on B-cells and investigation of its structure-function relationship.

@article{Hu1992MitogenicAO,
  title={Mitogenic activity of (-)epigallocatechin gallate on B-cells and investigation of its structure-function relationship.},
  author={Z Q Hu and Masahiro Toda and Seiji Okubo and Yukihiko Hara and Tadakatsu Shimamura},
  journal={International journal of immunopharmacology},
  year={1992},
  volume={14 8},
  pages={1399-407}
}
(-)Epigallocatechin gallate (EGCg), the main constituent of green tea, strongly enhanced the direct plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in vitro and showed strong mitogenic activity for mouse splenic B-cells but not for splenic T-cells and thymocytes. The enhancement of B-cell proliferation was not mediated by macrophages since their removal did not eliminate the activity. Among the derivatives of catechin examined, (+)catechin (C); (-)epicatechin (EC… CONTINUE READING