Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors

@inproceedings{Lipton1984MitogenicSO,
  title={Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors},
  author={Allan Lipton and C Cano and Kim Leitzel},
  year={1984}
}
There is evidence that platelets are involved in the hematogenous spread of malignant tumors. Certain tumor cells aggregate platelet in vitro (1–4) and an intimate relationship between platelets and tumor cells is further suggested by ultrastructural studies in vivo which show arrested tumor emboli surrounded by platelets (5–8). Certain tumor lines also induce thrombocytopenia in vivo (1,5,9). The reasons for this close platelet-tumor cell relationship are speculative at present. Possibilities… CONTINUE READING

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