Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

  title={Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts},
  author={K. Irani and Y. Xia and J. Zweier and S. Sollott and C. Der and E. Fearon and M. Sundaresan and T. Finkel and P. Goldschmidt-Clermont},
  pages={1649 - 1652}
  • K. Irani, Y. Xia, +6 authors P. Goldschmidt-Clermont
  • Published 1997
  • Biology, Medicine
  • Science
  • NIH 3T3 fibroblasts stably transformed with a constitutively active isoform of p21Ras, H-RasV12 (v-H-Ras or EJ-Ras), produced large amounts of the reactive oxygen species superoxide (·O2−). ·O2− production was suppressed by the expression of dominant negative isoforms of Ras or Rac1, as well as by treatment with a farnesyltransferase inhibitor or with diphenylene iodonium, a flavoprotein inhibitor. The mitogenic activity of cells expressing H-RasV12 was inhibited by treatment with the chemical… CONTINUE READING
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