Mitogen-stimulated release of inositol phosphates in human fibroblasts.

@article{Jamieson1987MitogenstimulatedRO,
  title={Mitogen-stimulated release of inositol phosphates in human fibroblasts.},
  author={Graham A Jamieson and Mitchel L Villereal},
  journal={Archives of biochemistry and biophysics},
  year={1987},
  volume={252 2},
  pages={478-86}
}
Mitogenic stimulation of quiescent human fibroblasts (HSWP) with a growth factor mixture (consisting of epidermal growth factor (EGF), insulin, bradykinin, and vasopressin) rapidly induces an increase in Na influx via a Ca-mediated activation of an amiloride-sensitive Na/H exchanger. Inositol phosphates (specifically inositol-1',4',5'-phosphate) have been implicated in mediating the mobilization of intracellular Ca stores in other cell types and we have now completed a detailed analysis of the… CONTINUE READING

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Assays performed in the presence of lithium , which inhibits inositol phosphate monophosphatase , promotes the prolonged and enhanced accumulation of inositol monophosphate .
The effects of different combinations of these growth factors and of the bee venom peptide , melittin , have also been determined .
Assays performed in the presence of lithium , which inhibits inositol phosphate monophosphatase , promotes the prolonged and enhanced accumulation of inositol monophosphate .
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