Mitogen-stimulated lymphocytes release biologically active corticotropin.


We demonstrate that mitogen-activated lymphocytes release a biologically active form of ACTH that stimulates the in vitro release of corticosterone from cocultured rat adrenal cells. Neither nonstimulated lymphocytes nor the addition of mitogens alone to adrenal cell cultures had an effect. The steroidogenic activity could be neutralized by rabbit anti-ACTH… (More)


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@article{Clarke1993MitogenstimulatedLR, title={Mitogen-stimulated lymphocytes release biologically active corticotropin.}, author={Bart L Clarke and Bernd Gebhardt and James Edwin Blalock}, journal={Endocrinology}, year={1993}, volume={132 3}, pages={983-8} }