Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities.

  title={Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities.},
  author={Karine M{\'e}rienne and Solange Pannetier and Annick Harel-Bellan and Paolo Sassone-Corsi},
  journal={Molecular and cellular biology},
  volume={21 20},
The protein kinase ribosomal S6 kinase 2 (RSK2) has been implicated in phosphorylation of transcription factor CREB and histone H3 in response to mitogenic stimulation by epidermal growth factor. Binding of phospho-CREB to the coactivator CBP allows gene activation through recruitment of the basal transcriptional machinery. Acetylation of H3 by histone acetyltransferase (HAT) activities, such as the one carried by CBP, has been functionally coupled to H3 phosphorylation. While various lines of… CONTINUE READING

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