Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1

@inproceedings{Zhang2008MitogeninducedRO,
  title={Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1},
  author={Hongmei Zhang and Li Li and Nektaria D. Papadopoulou and Glenn Hodgson and Emma Evans and Matthew D Galbraith and Mark S Dear and St{\'e}phanie Vougier and Janice Saxton and Peter E. Shaw},
  booktitle={Nucleic acids research},
  year={2008}
}
Many eukaryotic genes are acutely regulated by extra-cellular signals. The c-fos serum response element (SRE) mediates transcriptional activation in response to mitogens through serum response factor (SRF)-dependent recruitment of Elk-1, a mitogen-activated protein kinase (MAPK)-responsive transcription factor. How subsequent events at SRE promoters stimulate initiation of transcription has yet to be fully resolved. Here we show that extra-cellular signal-regulated kinase (ERK) and mitogen and… CONTINUE READING

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