Mitogen activation of resting lymphocytes exposes cryptic insulin receptors.

@article{Goodman1993MitogenAO,
  title={Mitogen activation of resting lymphocytes exposes cryptic insulin receptors.},
  author={D W Goodman and Peter C. Isakson},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 6},
  pages={
          4207-15
        }
}
Mitogen activation of resting lymphocytes induces expression of high affinity insulin receptors on the plasma membrane. The mechanism underlying this effect on insulin receptor expression was examined by comparing levels of insulin receptor mRNA and protein in resting and mitogen-activated rodent lymphocytes. Analysis of RNA levels indicated that resting and concanavalin A-activated lymphocytes contained equivalent amounts of insulin receptor mRNA with predominant transcripts of 7.9 and 9.5… Expand
Insulin Promotes and Cyclic Adenosine 3',5'-Monophosphate Impairs Functional Insertion of Insulin Receptors in the Plasma Membrane of Rat Adipocytes: Evidence for Opposing Effects of Tyrosine and Serine/Threonine Phosphorylation.
TLDR
The data suggest that insulin exposure leads to the uncovering of cryptic receptors associated with the PM, and it is suggested that tyrosine phosphorylation promotes this process, whereas enhanced serineosphorylation impairs the functional insertion of the receptors, rendering them unable to bind insulin. Expand
Inhibitors of the insulin receptor tyrosine kinase.
TLDR
The study of tyrosine kinase inhibitors, whether synthetically produced or purified from microorganisms or humans, has led to elucidation of molecular details of physiological insulin signaling. Expand
Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid
The toxicity of palmitic acid (PA) towards a human T‐lymphocyte cell line (Jurkat) has been previously investigated but the mechanism(s) of PA action were unknown. In the current study, Jurkat cellsExpand
The Immuno-Endocrine System: Hormones, Receptors and Endocrine Function of Immune Cells. The Packed-Transport Theory
TLDR
It is proposed that under the control of the nervous system immune cells produce hormones for general regulation, for intrasystem regulation and for remote, local regulation. Expand
Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice
TLDR
A novel mouse model exhibiting a FLAG-tagged mouse IR on T cells on the C57BL/6 background, which is not susceptible to developing T1D is developed, providing a novel platform for investigating the influence of IR expression on T cell trafficking and the development of insulitis. Expand
Glucose transporter expression on the plasma membrane of resting and activated white blood cells
TLDR
The objective was to examine the effects of activation by Phorbol 12‐myristate 13‐acetate (PMA) or lipopolysaccharide (LPS) and insulin on the expression of GLUT isoforms in all subpopulations of WBC. Expand
[The immuno-endocrine system. A new endocrine theory: the problem of the packed transport].
  • G. Csaba
  • Biology, Medicine
  • Orvosi hetilap
  • 2011
TLDR
The packed transport theory attempts to explain the mechanism and importance of the immuno-endocrine system, which has been considered from endocrinological point of view, underlying the important differences between the "classical" and immune cells. Expand
Hormones in the immune system and their possible role. A critical review.
  • G. Csaba
  • Biology, Medicine
  • Acta microbiologica et immunologica Hungarica
  • 2014
Immune cells synthesize, store and secrete hormones, which are identical with the hormones of the endocrine glands. These are: the POMC hormones (ACTH, endorphin), the thyroid system hormones (TRH,Expand
Essential Role for Neutrophil Recruitment to the Liver in Concanavalin A-Induced Hepatitis 1
TLDR
The concept that neutrophils play an important and previously unrecognized role in governing Con A-induced CD4+ T cell recruitment to the liver and the subsequent development of hepatitis is supported. Expand
Prediabetes uncovers differential gene expression at fasting and in response to oral glucose load in immune cells.
TLDR
Prediabetes uncovers constitutive TLR activation, enhanced IFN-γ signaling, and Treg dysfunction at fasting along with altered gene expression response to oral glucose load. Expand
...
1
2
...