Mitogen-activated protein kinases in innate immunity

@article{Arthur2013MitogenactivatedPK,
  title={Mitogen-activated protein kinases in innate immunity},
  author={J. Simon C. Arthur and Steven C. Ley},
  journal={Nature Reviews Immunology},
  year={2013},
  volume={13},
  pages={679-692}
}
  • J. Arthur, S. Ley
  • Published 1 September 2013
  • Biology, Medicine
  • Nature Reviews Immunology
Following pathogen infection or tissue damage, the stimulation of pattern recognition receptors on the cell surface and in the cytoplasm of innate immune cells activates members of each of the major mitogen-activated protein kinase (MAPK) subfamilies — the extracellular signal-regulated kinase (ERK), p38 and Jun N-terminal kinase (JNK) subfamilies. In conjunction with the activation of nuclear factor-κB and interferon-regulatory factor transcription factors, MAPK activation induces the… 
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References

SHOWING 1-10 OF 167 REFERENCES
Regulation of the immune response by stress‐activated protein kinases
TLDR
What is currently known about the role of two sub‐groups of SAPKs – c‐Jun NH2‐terminal kinase and p38 MAPK‐in the function of specific components of the immune system and the overall contribution to the immune response is summarized.
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
TLDR
PAC-1 is a key positive regulator of inflammatory cell signaling and effector functions, mediated through Jnk and Erk mitogen-activated protein kinase crosstalk.
Signaling in innate immunity and inflammation.
TLDR
Although the role of inflammation is to resolve infection and injury, increasing evidence indicates that chronic inflammation is a risk factor for cancer.
Targeting of TAK1 in inflammatory disorders and cancer.
  • H. Sakurai
  • Biology
    Trends in pharmacological sciences
  • 2012
Mitogen-Activated Protein Kinase Phosphatase 2 Regulates the Inflammatory Response in Sepsis
TLDR
Data support a mechanism by which MKP-2 targets ERK deactivation, thereby decreasingMKP-1 and thus removing the negative inhibition of MKp-1 on cytokine production, which is needed for sepsis to be eliminated.
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
TLDR
MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases.
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
TLDR
The mechanisms of MAPKAPK activation by the different MAPKs are reviewed and their physiological roles based on established substrates and recent discoveries are discussed.
Acetylation of MEK2 and IκB kinase (IKK) activation loop residues by YopJ inhibits signaling
TLDR
The results establish a hitherto uncharacterized mode of action for bacterial toxins and suggest the possibility that serine/threonine acetylation may occur even under nonpathogenic conditions and may be a widespread protein modification regulating protein function in eukaryotic cells.
Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way
Mycobacteria activate a series of macrophage signalling pathways upon engaging host cell receptors and during the invasion process. These signals initiate a cascade of events leading to the
...
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