Mitogen-activated protein kinases and asthma.

  title={Mitogen-activated protein kinases and asthma.},
  author={Girolamo Pelaia and Giovanni Cuda and Alessandro Vatrella and Luca Gallelli and Michele Caraglia and Monica Marra and Alberto Abbruzzese and Mario Caputi and Rosario Maselli and F. S. Costanzo and Serafino Antonio Marsico},
  journal={Journal of cellular physiology},
  volume={202 3},
Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical features of asthma including T cell activation, eosinophil and mast cell infiltration, as well as bronchial hyperresponsiveness and airway remodelling… CONTINUE READING

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