Mitogen-activated protein kinase stimulation of Ca(2+) signaling is required for survival of endoplasmic reticulum stress in yeast.

@article{Bonilla2003MitogenactivatedPK,
  title={Mitogen-activated protein kinase stimulation of Ca(2+) signaling is required for survival of endoplasmic reticulum stress in yeast.},
  author={Myriam Bonilla and Kyle W Cunningham},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 10},
  pages={
          4296-305
        }
}
  • Myriam Bonilla, Kyle W Cunningham
  • Published in Molecular biology of the cell 2003
  • Medicine, Biology
  • Endoplasmic reticulum (ER) stress in the budding yeast Saccharomyces cerevisiae triggers Ca2+ influx through a plasma membrane channel composed of Cch1 and Mid1. This response activates calcineurin, which helps to prevent cell death during multiple forms of ER stress, including the response to azole-class antifungal drugs. Herein, we show that ER stress activates the cell integrity mitogen-activate protein kinase cascade in yeast and that the activation of Pkc1 and Mpk1 is necessary for… CONTINUE READING

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