Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity.

@article{Fischer2009MitogenactivatedPK,
  title={Mitogen-activated protein kinase-signaling regulates the ability of M{\"u}ller glia to proliferate and protect retinal neurons against excitotoxicity.},
  author={Andy J Fischer and Melissa A. Scott and Eric R. Ritchey and Patrick Sherwood},
  journal={Glia},
  year={2009},
  volume={57 14},
  pages={1538-52}
}
The purpose of this study was to investigate whether insulin, fibroblast growth factor (FGF), and mitogen-activated protein kinase (MAPK) pathways protect retinal neurons against excitotoxicity and regulate the proliferation of Müller glia. We found that intraocular injections of insulin or FGF2 had variable effects upon the phosphorylation of ERK1/2, p38 MAPK, and CREB, and the expression of immediate early genes, cFos and Egr1. Accumulations of pERK1/2, p38 MAPK, pCREB, cFos and Egr1 in… CONTINUE READING

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