Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.

@article{Wancket2012MitogenactivatedPK,
  title={Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.},
  author={Lyn M. Wancket and Xiaomei Meng and Lynette K. Rogers and Yusen Liu},
  journal={Toxicologic pathology},
  year={2012},
  volume={40 8},
  pages={1095-105}
}
c-Jun N-terminal kinase (JNK) activation promotes hepatocyte death during acetaminophen overdose, a common cause of drug-induced liver failure. While mitogen-activated protein kinase (MAPK) phosphatase (Mkp)-1 is a critical negative regulator of JNK MAPK, little is known about the role of Mkp-1 during hepatotoxicity. In this study, we evaluated the role of… CONTINUE READING