Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.

  title={Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.},
  author={George W Small and Yue Y. Shi and Linda Slanec Higgins and Robert Z. Orlowski},
  journal={Cancer research},
  volume={67 9},
The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large proportion of breast cancers, and in some systems interferes with chemotherapy-mediated proapoptotic signaling through c-Jun-NH(2)-terminal kinase (JNK). We therefore sought to examine whether MKP-1 is a mediator of breast cancer chemoresistance using A1N4-myc human mammary epithelial cells, and BT-474 and MDA-MB-231 breast carcinoma cells. Transient or stable overexpression of MKP-1 reduced caspase… CONTINUE READING


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