Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death.

Abstract

Camptothecins are commonly used chemotherapeutics; in some models, they enhance signaling via the mitogen-activated protein kinase (MAPK) pathway through effects on upstream kinases. To evaluate the impact of camptothecin (CPT) on MAPKs in human colon cancer, we studied HCT116 and CaCo2 colon cancer cells. We found that HCT116 cells highly express mitogen… (More)
DOI: 10.4161/cbt.26044

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@article{Lee2013MitogenactivatedPK, title={Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death.}, author={Minyoung Lee and Sun Young Kim and Jongguk Kim and Hak-Su Kim and Sang-Man Kim and Eun Ju Kim}, journal={Cancer biology & therapy}, year={2013}, volume={14 11}, pages={1007-15} }