Mitogen-activated protein kinase pathways in osteoblasts.

  title={Mitogen-activated protein kinase pathways in osteoblasts.},
  author={Matthew Blake Greenblatt and Jae-Hyuck Shim and L. H. Glimcher},
  journal={Annual review of cell and developmental biology},
Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well characterized as mediators of inflammation and neoplastic transformation. Recent work has expanded our understanding of their developmental functions, particularly in the regulation of bone mass via control of osteoblast differentiation. Here, we review the functions of MAPK pathways in osteoblasts, including a consideration of MAPK substrates. In particular, MAPKs function to regulate the key transcriptional… CONTINUE READING

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