Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.

@article{Mori2002MitogenactivatedPK,
  title={Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.},
  author={Tatsuro Mori and Xiaoying Wang and Jae-Chang Jung and Toshihisa Sumii and Aneesh Bhim Singhal and Mary Elizabeth Fini and Clifton Edward Dixon and Alessandro Alessandrini and Eng H. Lo},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2002},
  volume={22 4},
  pages={
          444-52
        }
}
The authors provide the first in vitro and in vivo evidence that perturbations in mitogen-activated protein kinase (MAPK) signal-transduction pathways are involved in the pathophysiology of traumatic brain injury. In primary rat cortical cultures, mechanical trauma induced a rapid and selective phosphorylation of the extracellular signal-regulated kinase (ERK) and p38 kinase, whereas there was no detectable change in the c-jun N-terminal kinase (JNK) pathway. Treatment with PD98059, which… CONTINUE READING

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