Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.

@article{Montero2002MitogenactivatedPK,
  title={Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.},
  author={Juan Carlos Montero and Laura Cano Yuste and Elena D{\'i}az-Rodr{\'i}guez and Azucena Espar{\'i}s-Ogando and Atanasio Pandiella},
  journal={The Biochemical journal},
  year={2002},
  volume={363 Pt 2},
  pages={
          211-21
        }
}
Solubilization of a number of membrane proteins occurs by the action of cell-surface proteases, termed secretases. Recently, the activity of these secretases has been reported to be controlled by the extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and the p38 mitogen-activated protein kinase (MAPK) routes. In the present paper, we show that shedding of membrane-anchored growth factors (MAGFs) may also occur through MAPK-independent routes. In Chinese-hamster ovary cells, cleavage… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Long-range signal transmission in autocrine relays.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins.

  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2012